4/13/2023 0 Comments Pepe gamez biography![]() ![]() Malignant mesothelioma (MM) is a rare and aggressive tumor which mainly originates from pleural and peritoneal mesothelial cells. This study may have clinical implications for the development of targeted therapy approaches for MM. This study demonstrated that combined treatment with two inhibitors counteracting the activation of two different signaling pathways involved in neoplastic transformation and progression, such as those activated by ErbB and Hh signaling, is more effective than the single treatments in reducing MM growth in vitro and in vivo. The efficacy of the combined treatment was also evaluated in a murine epithelioid MM cell line both in vitro and in vivo. The aim of this study was to evaluate the effects of inhibitors of Hh- (GANT-61) and ErbB receptors (Afatinib)-mediated signaling pathways, when used alone or in combination, on growth, cell cycle, cell death and autophagy, modulation of molecules involved in transduction pathways, in three human MM cell lines of different histotypes. ![]() Thus, molecules involved in these signaling pathways could be used for targeted therapy approaches. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM. ![]() Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates.
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